A bitter Bajoran herbal preparation Kira Nerys takes while carrying the O'Briens' child, which also happens to counteract sedatives and so saves her life.
Makara herbs feature in the Deep Space Nine episode The Darkness and the Light. Kira, acting as surrogate for Keiko and Miles O'Brien's baby, is prescribed the herbs by Julian Bashir to help her body sustain the pregnancy, and complains at length about the taste.
The detail becomes important at the end of the episode. Silaran Prin, a Cardassian disfigured by one of Kira's wartime bombings, captures her and intends to cut the child from her body before killing her. He agrees to give her a sedative first.
Because makara herbs work against sedatives, the drug does not put her under. Kira feigns unconsciousness, overpowers Prin and kills him with his own weapon.