The Daystrom Institute department in Okinawa where Bruce Maddox worked to build synthetic life, reduced to theory and simulation after the Federation banned synthetics in 2385.
The Division of Advanced Synthetic Research is the branch of the Daystrom Institute devoted to creating artificial beings. Under Bruce Maddox it tried for years to reproduce the work of Noonien Soong, and it produced the simpler synthetic labourers used at the Utopia Planitia shipyards.
When those workers attacked Mars in 2385, the Federation outlawed synthetic life and the division was all but closed. In the Picard episode Remembrance, Jean-Luc Picard visits its quiet laboratory and meets Doctor Agnes Jurati, who explains that the staff may now only study and model.
She shows him the dismantled android B-4 and describes Maddox's theory of fractal neuronic cloning, by which a pair of new androids could be grown from a single positronic neuron of Data.