A rough frontier planet of bars and informants where Captain Freeman's team hunted for the whereabouts of Nick Locarno in 2381.
New Axton appears in the Lower Decks episode The Inner Fight. Starfleet has learned that someone is targeting former officers with troubled records, and the USS Cerritos is ordered to find Nicholas Locarno, the disgraced leader of Nova Squadron, before the unknown attacker does. His trail leads to New Axton.
Captain Freeman goes down with Shaxs and Rutherford and finds a place where nobody will talk to a Starfleet uniform. Their attempts to buy or bully information out of the locals go nowhere.
Chief Engineer Billups, working separately in the guise of a bounty hunter, has more success. The team reaches Locarno's hideout and discovers plans for the mysterious ship that has been attacking vessels across the quadrant, showing that Locarno is not a victim but the culprit.