A Nebula-class Federation starship that is carrying Benjamin Sisko and the prisoner Gul Dukat to a war crimes hearing in 2374 when Cardassian destroyers attack and destroy it, in the episode Waltz.
The USS Honshu is a Nebula-class starship seen in the sixth-season Star Trek: Deep Space Nine episode Waltz. In 2374 she is taking Gul Dukat, captured at the end of the Dominion's occupation of Deep Space 9, to a special jury hearing on his war crimes. Sisko is aboard as a witness.
On the way a wing of Cardassian destroyers attacks the ship. The Honshu is destroyed with heavy loss of life, though a number of escape pods get clear. Dukat pulls the injured Sisko into a shuttle and lands on a nearby planet, where the rest of the episode unfolds as Dukat's delusions and self-justification come into the open.
The Defiant, under Worf, searches for survivors against a deadline to join a troop convoy, and finds Sisko in the final hours.