The classroom opened on Deep Space 9's Promenade by Keiko O'Brien to teach the station's children, later bombed during a dispute over the teaching of the wormhole.
Keiko O'Brien, a botanist with little to do on the station, proposes a school in A Man Alone after seeing Jake Sisko and Nog running wild. Sisko gives her a room on the Promenade, and her first pupils include Jake and, after some resistance from his father Rom, Nog.
In In the Hands of the Prophets, Vedek Winn objects to Keiko teaching that the wormhole was built by aliens rather than by the Prophets. Bajoran parents withdraw their children, and the schoolroom is wrecked by a bomb planted as part of a plot against Vedek Bareil.
The school reopens, but its numbers dwindle as families leave the station amid the Dominion threat. In The House of Quark, with only Jake and Nog left, Keiko closes it, and she soon afterwards joins a botanical expedition on Bajor.