One of three Orion women given to Archer in 2154 as a supposed gift, whose pheromones were meant to cripple the crew so that Enterprise could be captured.
D'Nesh appears in the fourth-season Enterprise episode Bound, played by Crystal Allen. With her sisters Navaar and Maras, she is presented to Archer by the Orion privateer Harrad-Sar during talks about a mining venture.
The women give off pheromones that make human males aggressive and suggestible and give the women headaches. D'Nesh turns her attention to Commander Kelby in engineering, playing on his resentment of Tucker until he sabotages the engines.
Tucker and T'Pol, shielded by their mental bond, stop the plot. It then emerges that among Orions it is the women who rule, and that Harrad-Sar is in truth the servant of the three sisters.