A Danube-class runabout assigned to Deep Space 9, which joins the mission to rescue Sisko from the Jem'Hadar and is lost in 2371 during the Tal Shiar and Obsidian Order attack on the Founders.
The USS Mekong is one of the runabouts stationed at Deep Space 9 in Star Trek: Deep Space Nine, named like the others after a river of Earth. It first appears in The Jem'Hadar at the end of 2370, when it flies into the Gamma Quadrant with the Orinoco and the starship Odyssey to recover Sisko and Quark.
During 2371 it is used on many assignments, among them Kira and Odo's pursuit of a Maquis ship in Heart of Stone. In Improbable Cause Odo and Garak take it to look for Enabran Tain and are seized by a Romulan warbird.
In The Die Is Cast the two escape in the runabout as the combined Romulan and Cardassian fleet is destroyed by the Jem'Hadar in the Omarion Nebula. The Mekong is crippled, and the Defiant beams them out just before it is destroyed.