Starbase 80 is a run-down, understaffed starbase with a cursed reputation, which ends the series as the hub of multiverse exploration.
Starbase 80 is known throughout Starfleet as a dead-end posting, understaffed and supplied with obsolete equipment. In Trusted Sources, Freeman transfers Mariner there, prompting her to resign.
In Starbase 80?!, the Cerritos is forced to dock at the station, and Mariner believes it to be cursed when crew members begin acting like zombies. The cause is Clem, an anaphasic lifeform picked up on an earlier mission, who is invited to stay, and the crew helps repair many of the station's problems.
In The New Next Generation, Starbase 80's outdated systems make it immune to the effects of an interdimensional rift. The station is repurposed and relocated to oversee Starfleet's exploration of the multiverse, with Carol and Alonzo Freeman assigned there.