A lawless district of M'Talas Prime where Raffi Musiker works undercover in 2401, tracing stolen experimental weapons through its criminal underworld.
District Six is an area of the planet M'Talas Prime, seen in the third season of Picard. Crowded, neon-lit and run by criminals, it is where Raffi Musiker poses as a relapsed addict while working for Starfleet Intelligence under a handler she never sees.
In The Next Generation she chases a lead about a stolen portal weapon and a so-called Red Lady, realising too late that the phrase means a red statue of Rachel Garrett outside a Starfleet recruitment building, which the weapon then destroys.
Refusing to drop the case, she returns to the district in Disengage to buy an audience with the Ferengi broker Sneed, who sees through her story and has her drugged. She is saved by her handler, who proves to be Worf, and the two continue the investigation together in Seventeen Seconds.